Mucolytics for COPD: negotiating a slippery slope towards proof of efficacy.
نویسنده
چکیده
Mucolytics are medicines that modulate mucus production and decrease mucus viscosity. Their mucus thinning effects may improve mucociliary transport and thereby facilitate expectoration of mucus out of the distal bronchial tree [1]. Improved clearance and expectoration of mucus can prevent mucus plugging of small airways and may theoretically improve gas exchange and lessen the probability of post-obstructive infection. Through these complementary effects, mucolytics could potentially play a role in reducing exacerbations in chronic obstructive pulmonary disease (COPD) [2].
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ورودعنوان ژورنال:
- The European respiratory journal
دوره 50 4 شماره
صفحات -
تاریخ انتشار 2017